Six facts about surface area and volume.

Large organisms have a small surface area to volume ratio.

Some organisms have a body shape adapted to increase their surface area e.g. flatworms.

Some large, active organisms have specially adapted surfaces for gas exchange e.g. lungs and gills.

The mesophyll cells of flowering plants provide a large respiratory surface.

Some large, active organisms use ventilation mechanisms to ensure a constant concentration gradient.

Organisms use transport systems to bring substances to cells by mass flow.